Metabolic bone disease is an umbrella term referring to abnormalities of bones caused by a broad spectrum of disorders.
Conditions considered to be metabolic bone disorders include osteoporosis, osteomalacia (adults) and rickets (children), osteitis fibrosa cystica, Paget's disease of bone, pyramiding (turtles), and others.
CDRG’s research focuses on the epidemiology and treatment of osteoporosis and related conditions using observational data. In observational data, selection bias and regression-to-the-mean problems can result due to how physicians determine specific treatments for their patients. Thorough consideration of all such issues, with the help of advanced statistical tools, is essential.
Mineral metabolism disorders result from abnormal levels of minerals, either too much or too little, in the blood. These disorders, often present in chronic kidney disease patients, are associated with risk of fractures, vascular calcification, arterial stiffness, ventricular hypertrophy, hospitalization, and even mortality.
CDRG’s research centers around mineral metabolism disorder epidemiology, relationships with clinical outcomes, and treatment in kidney disease patients. The relationships among the minerals in the blood are complex and treatment of abnormal levels can have complex effects, making appropriate study complicated and challenging. Careful study design and selection of correct statistical methods is necessary for successful studies. CDRG has extensive experience in designing and carrying out such studies.
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