Skip to the content

Not a One Size Fits All


Research questions can be complicated, often requiring out-of-the-box thinking and techniques. Based on the research questions and data for the study, our biostatistical and epidemiological teams properly design studies and analyze the data. For the past two decades, CDRG has worked with Medicare Research Identifiable Files, including the 20% sample and specific 100% cohort samples. Our understanding of and proficiency with the Medicare data allow us to move beyond basic methods into advanced modeling.


In surveillance research, some of the methods we use is employing Bayesian models to produce stable event rate estimates for small groups/regions. In trend analysis, we also use penalized spline generalized additive models to assess the “event” trend over time. Additionally, in provider profiling, we use random effects modeling and Bayesian techniques to stabilize estimates for small providers. In post-marketing research, we use nested case-control studies to evaluate the safety and benefit of the study drug, and we use the difference-in-difference method to evaluate the effect of policy changes. We also use two-part modeling to compare medical costs and healthcare resource utilization and we use random forest and LASSO regression for variable selection in prediction models. We also use simulation to evaluate which statistical methods we should choose, based on the unique case we're working with.

Additionally, comparative effectiveness research (CER) using observational data is a major aspect of our studies. An important task for CER with observational data is to adjust for biases from multiple sources. We apply state-of-the-art methodologies, such as propensity score methods, marginal structural models, doubly robust methods, and instrumental variable analysis, to best correct biases as necessary.

Since our strategies are tailored to fit your specific project, these are only some of the methods we employ. We tap into additional techniques as needed to fit your specific project needs.

Have questions about how we can help you with your next project?

Contact Us

Contact Us

Chronic Disease Research Group

Hennepin Healthcare Research Institute

701 Park Ave.

Suite S2.100

Minneapolis, MN 55415


Tel: 612.873.6200

Mon-Fri: 8:00 AM - 4:30 PM CT

The Chronic Disease Research Group (CDRG) is a division of the Hennepin Healthcare Research Institute (formerly known as the Minneapolis Medical Research Foundation), located in Minneapolis, MN